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Journal: Journal of Neuroinflammation
Article Title: TRIM21 promotes astrocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis by stabilizing RGMa via K33-linked ubiquitination
doi: 10.1186/s12974-026-03769-4
Figure Lengend Snippet: TRIM21 is elevated in astrocytes across MS. A Analysis of TRIM21 mRNA expression in the control and white matter lesion tissues of MS patients based on gene expression profiling microarray data ( GSE138614 ). B TRIM21 mRNA levels in PBMC samples of healthy controls (n = 12) and MS patients (n = 20) were quantified by RT-qPCR. C Representative immunoblots and corresponding quantification of TRIM21 protein levels in brain tissues from EAE mice at 28 dpi (n = 5). D Representative immunoblot images and the corresponding quantitative analysis of TRIM21 protein expression in spinal cord tissues from EAE mice at 28 dpi (n = 5). E Immunofluorescence co-localization analysis of TRIM21 (red) and the astrocyte marker GFAP (green) in brain and spinal cord sections from control and EAE mice at 28 dpi (n = 5). Scale bar, 50 µm
Article Snippet: The
Techniques: Expressing, Control, Gene Expression, Microarray, Quantitative RT-PCR, Western Blot, Immunofluorescence, Marker
Journal: Scientific Reports
Article Title: SIRT3 suppresses renal cancer progression by regulating IDH2 acetylation
doi: 10.1038/s41598-026-37783-6
Figure Lengend Snippet: SIRT3 is downregulated in RCC. ( A ) Based on the GEO GSE53757 dataset, SIRT3 mRNA levels in RCC tissues were compared with those in normal tissues. ( B ) SIRT3 protein levels in RCC tissues were analyzed in comparison to adjacent normal tissues using CPTAC data. ( C ) SIRT3 protein levels in RCC tissues and normal tissues were detected using immunohistochemistry (IHC). A scatter plot was generated to display the expression of SIRT3 in adjacent normal tissues versus RCC tissues. ( D, E ) Enrichment plots were produced to illustrate the gene expression signatures for proliferation (CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_DN) and migration (GOBP_ENDOTHELIAL_CELL_MIGRATION). *** P < 0.001.
Article Snippet: The
Techniques: Comparison, Immunohistochemistry, Generated, Expressing, Produced, Gene Expression, Migration